Testosterone levels naturally decline with age, TRT is considered when the deficiency causes significant symptoms that negatively impact a man's quality of life. The therapy aims to restore testosterone to a optimal range, which can improve sexual function, boost energy levels, and enhance mood and a sense of well-being. Some men may also experience increased bone density and muscle mass, as well as a reduction in body fat.

Symptoms of low testosterone can include:

Sexual changes: Low sex drive, fewer spontaneous erections, erectile dysfunction, and infertility.

Physical changes: Reduced muscle mass and strength, increased body fat (especially around the abdomen), decreased bone density, loss of body or facial hair, and fatigue.

Mental and emotional changes: Depressed mood, irritability, difficulty concentrating, memory problems, low motivation, and a general decrease in well-being.